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Each serving should be taken on an empty stomach just prior to a meal and stay well-hydrated while on the product

The triple DOR mutant T358A/T361A/S363G is still able to internalize but only when arrestin 3 is expressed

That is why the documented practice is to dose on an empty stomach a common rule of thumb in the research framing is a fasted window before and after the injection, with no food or caloric drinks in that window